GroEL/ESチャペロニンは,そのメカニズムを調節し, TIM-barrel領域の折り畳み速度を加速します

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Updated: Feb 9, 2026

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
00:52

¹H NMR of Conformationally Flexible Molecules: Temporal Resolution

1.3K

Florian Georgescauld1, Kristina Popova1, Amit J Gupta1

  • 1Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82159 Martinsried, Germany.

Cell
|May 13, 2014
PubMed
まとめ

GroEL/ESチャペロニンシステムは,DapA.のような基板におけるセグメンタル構造の形成を促進することによって,タンパク質の折り畳みを加速します. このチャペロニン補助の折りたたみは,単独で効率的に折りたたむことができないタンパク質にとって不可欠であり,結合を防止します.

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