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Updated: Apr 16, 2026

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
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RIPK1は,RIPK3-MLKLによって引き起こされる全身性炎症と緊急出血を調節する

James A Rickard1, Joanne A O'Donnell1, Joseph M Evans2

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3050, Australia.

Cell
|May 13, 2014
PubMed
まとめ

RIPK1が欠けているマウスは炎症で死亡しますが,死滅を防ぐことはこれを防ぐことができます. RIPK1は通常,死滅を抑制することによって炎症を抑制し,炎症反応の制御における新しい役割を明らかにします.

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