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Updated: Apr 30, 2026

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
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RIPK1は,カスパーゼ8とRIPK3によって媒介される早期産後死亡率を阻害する

Christopher P Dillon1, Ricardo Weinlich1, Diego A Rodriguez1

  • 1Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|May 13, 2014
PubMed
まとめ

受容体相互作用タンパク質キナーゼ1 (RIPK1) 欠乏症は致死性を引き起こすが,RIPK1とRIPK3のノックアウトとカスパゼ8またはFADDの消去を組み合わせれば生存が可能である. RIPK1は細胞死経路を調節し,炎症と死滅に影響を与えます.

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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells09:15

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