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Updated: Apr 30, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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繰り返し発生する非還元ポリケチド合成酵素の体系的なドメインスワップは,触媒的再プログラミングのメカニズム的理解と論理的根拠を提供します

Adam G Newman1, Anna L Vagstad, Philip A Storm

  • 1Department of Chemistry, The Johns Hopkins University , 3400 N. Charles Street, Baltimore, Maryland 21218, United States.

Journal of the American Chemical Society
|May 13, 2014
PubMed
まとめ

エンジニアリングによる反復性非還元性ポリケチド合成酵素 (NR-PKSs) は,新種の代謝産物生産の鍵となる. ドメイン交換の成功には,効率的なドメインの相互作用と,自発的な脱線を上回る触媒速度が必要です.

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