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エシェリキヤ大腸菌III級リボヌクレオチド還元酵素に対する化学的に有能なチオスルフランイル基素

Yifeng Wei1, Guinevere Mathies, Kenichi Yokoyama

  • 1Departments of Chemistry and ‡Biology and §Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307, United States.

Journal of the American Chemical Society
|May 16, 2014
PubMed
まとめ

クラスIIIのリボヌクレオチド還元酵素 (RNRs) は,フォーマットを還元剤として使用します. 研究者らは,E. coliのRNRに新しいチオスルフラニルラジカル中間物質を発見し,DNA合成と修復のための新しい反応経路を明らかにした.

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