Mfsd2aは,血脳障壁の形成と機能に不可欠です
Ayal Ben-Zvi1, Baptiste Lacoste1, Esther Kur1
1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nature
|May 16, 2014
まとめ
科学者は,Mfsd2aが,トランサイトシスを抑制することによって,血液脳障壁 (BBB) の維持に不可欠であると特定しました. この発見は,中枢神経系 (CNS) への薬物投与を改善する可能性を秘めています.
科学分野:
- 神経科学は神経科学である.
- 血管生物学 血管生物学
- 発達生物学 発達生物学とは
背景:
- 血脳障壁 (BBB) は中枢神経系 (CNS) を保護するが,薬物の投与を阻害する.
- BBB形成を理解することは,治療目的でそれを操作する鍵です.
- BBBの完全性を制御する分子メカニズムに関する既存の知識は限られている.
研究 の 目的:
- 機能的なBBBの形成を制御する分子メカニズムを特定する.
- BBB形成と機能におけるMfsd2aの役割を調査する.
- 中枢神経系の薬物投与に対する治療的影響を探求する.
主な方法:
- ネズミの胚に新しいトレーサー注射法を使用して,BBBの発達を評価しました.
- BBB形成中にBBB特有の遺伝子をスクリーニングし,Mfsd2a.aに焦点を当てました.
- Mfsd2aの遺伝子除去と電子顕微鏡を用いて,BBBの構造と機能を分析した.
主要な成果:
- ネズミのBBBは,胚の日15.5 (E15.5) で機能するようになる.
- Mfsd2aは中枢神経系の血管で選択的に発現し,BBBの完全性にとって不可欠です.
- Mfsd2aの欠乏は,血管のパターン化や緊密な接合に影響を与えることなく,トランサイトーシスの増加と漏れやすいBBBにつながります.
結論:
- Mfsd2aは,BCB機能の重要な調節体であり,主にCNS内皮細胞の膀トランサイトーシスを阻害する.
- ペリサイトは,Mfsd2a発現を調節し,BBBの完全性を維持する.
- Mfsd2aのターゲティングは,中枢神経系への薬物投与を強化するための新しい戦略を提供することができます.
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