モダリティ特有のタラモコルチカルインプットは,ポストシナプスL4ニューロンのアイデンティティを指示する
Gabrielle Pouchelon1, Frédéric Gambino2, Camilla Bellone1
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland.
Nature
|May 16, 2014
まとめ
タラモコルチカル (TC) の入力形状は,皮質ニューロンを発達させる. タクティルの入力をノシセプティブの入力に置き換えることで,ニューロンは新しい感覚機能を採用し,回路の発達を変化させました.
科学分野:
- 神経科学は神経科学である.
- 発達神経科学とは
- 分子神経科学は分子神経科学である.
背景:
- 発達の過程で皮質領域のパターンが形成されるには,タラモコルチカル (TC) の入力が極めて重要です.
- ソマトセンサリー皮質の層4 (L4) のニューロンは,thalamusのventrobasalis (VB) と後部核 (Po) から異なる入力を受けます.
- L4ニューロンのアイデンティティは,TCの入力が差異化に影響することを示唆する,産後プラスチックです.
研究 の 目的:
- TC入力源がL4ニューロンの分子および機能的同一性を指示するかどうかを調査する.
- L4ニューロンが,回路組立中に変化したTC入力に基づいて,そのアイデンティティを尊重できるかどうかを判断する.
主な方法:
- 新生マウスのVB核の遺伝的消去.
- 主要体感覚皮質 (S1) のL4ニューロンへのポ発射の分析 (S1).
- 剥離後のL4ニューロンにおける分子および機能的変化の評価.
主要な成果:
- VBの消去により,Poの投影がS1 L4ニューロンに再配線する.
- 再指定されたL4ニューロンは,Po標的ニューロン特性を獲得し,VB標的特性を抑制しました.
- これらのニューロンは,通常のモダリティセグレゲーションとは異なり,触覚刺激と有害な刺激の両方に反応しました.
結論:
- TCの入力タイプは,L4ニューロンの分子および機能的差異化を特に制御します.
- この入力主導の可塑性は,モダリティ特有のニューロンおよび回路特性の発達を指示する.
- コルチコゲネシス中の感覚モダリティ統合のメカニズムを示しています.
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