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Updated: Apr 29, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

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キナーゼシグナル伝達複合体内のポジティブなフィードバックは,NF-κBの活性化のためのスイッチメカニズムとして機能します

Hisaaki Shinohara1, Marcelo Behar2, Kentaro Inoue1

  • 1Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

Science (New York, N.Y.)
|May 17, 2014
PubMed
まとめ

鍵となるタンパク質複合体は,B細胞における核因子-κB (NF-κB) の活性化のためのスイッチとして作用する. このスイッチはフィードバックに依存し,CARMA1のリン酸化はNF-κBBに不可欠です.

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