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Updated: Jul 13, 2026

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

古典的な反応パターンを超えて,ビニルおよびアリルアレンを,超分子触媒を用いて,価値あるβ-およびγ-アルデヒド中介物質に水酸化することで,

Paweł Dydio1, Remko J Detz, Bas de Bruin

  • 1van 't Hoff Institute for Molecular Sciences, University of Amsterdam , Science Park 904, 1098 XH, Amsterdam, The Netherlands.

Journal of the American Chemical Society
|May 21, 2014
PubMed
まとめ

この研究では,地域選択的水酸化処理のためのアニオン結合部位を内蔵した新しいロジウム触媒を導入しています. これらの触媒は,分子を事前組織化することによって,挑戦的な基板に対する高い選択性を達成し,商業的なアプリケーションを可能にします.

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Alkynes to Aldehydes and Ketones: Hydroboration-Oxidation

Introduction
One of the convenient methods for the preparation of aldehydes and ketones is via hydration of alkynes. Hydroboration-oxidation of alkynes is an indirect hydration reaction in which an alkyne is treated with borane followed by oxidation with alkaline peroxide to form an enol that rapidly converts into an aldehyde or a ketone. Terminal alkynes form aldehydes, whereas internal alkynes give ketones as the final product.
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