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メトフォーミンは,ミトコンドリアのグリセロフォスファート脱水素酸化酵素を阻害することによって,グルコン生成を抑制します

Anila K Madiraju1, Derek M Erion1, Yasmeen Rahimi2

  • 11] Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA [2] Department of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA [3] Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Nature
|May 23, 2014
PubMed
まとめ

メトホルミンは2型糖尿病の重要な薬であり,ミトコンドリアのグリセロフォスファート脱水素酸化酵素を阻害することによって作用します. この作用は細胞のリドックス作用を変化させ,グルコースの産生を減らし,低血糖症を伴わずに血糖を低下させます.

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