Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Point and Frameshift Mutations01:30

Point and Frameshift Mutations

1.8K
Point mutations are genetic alterations involving the change of a single nucleotide base pair in DNA. Depending on how the alteration affects protein synthesis, they can lead to various consequences.Point mutations fall into the following types:Silent mutations occur when a nucleotide change does not alter the amino acid sequence due to the redundancy of the genetic code. For instance, changing ACC to ACA still encodes threonine, leaving the protein function unaffected. This occurs because...
1.8K
From DNA to Protein03:06

From DNA to Protein

20.7K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
20.7K
Exon Recombination02:32

Exon Recombination

3.1K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.1K
Mutations01:39

Mutations

66.7K
Overview
66.7K
Mutations01:35

Mutations

31.2K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
31.2K
Mutations01:39

Mutations

11.0K
11.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Non-coding structural variants disrupt FOXG1 transcriptional regulation in early neurodevelopment.

Nature communications·2026
Same author

Cis-regulatory evolution shapes facial diversity in birds and mammals.

Science advances·2026
Same author

Multi-season analysis reveals hundreds of drought-responsive genes in sorghum.

The Plant journal : for cell and molecular biology·2026
Same author

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development.

bioRxiv : the preprint server for biology·2026
Same author

An expanded registry of candidate cis-regulatory elements.

Nature·2026
Same author

Uncovering hidden enhancers through unbiased in vivo testing.

Nature communications·2025

関連する実験動画

Updated: Apr 29, 2026

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
05:48

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

2.0K

野生でのコドン再配置を停止する.

Natalia N Ivanova1, Patrick Schwientek1, H James Tripp1

  • 1Department of Energy Joint Genome Institute (DOE JGI), Walnut Creek, CA 94598, USA.

Science (New York, N.Y.)
|May 24, 2014
PubMed
まとめ

この研究では,環境サンプルでストップコドンの再割り当てを含む,広範な遺伝子コードの変異が発見されました. これは,遺伝子コードの多様性と,これらの違いによるファグと宿主の潜在的な衝突を強調しています.

さらに関連する動画

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins
08:37

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins

Published on: April 30, 2018

7.2K
Microinjection of CRISPR/Cas9 Protein into Channel Catfish, Ictalurus punctatus, Embryos for Gene Editing
16:08

Microinjection of CRISPR/Cas9 Protein into Channel Catfish, Ictalurus punctatus, Embryos for Gene Editing

Published on: January 20, 2018

14.3K

関連する実験動画

Last Updated: Apr 29, 2026

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein
05:48

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

2.0K
A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins
08:37

A Rapid and Facile Pipeline for Generating Genomic Point Mutants in C. elegans Using CRISPR/Cas9 Ribonucleoproteins

Published on: April 30, 2018

7.2K
Microinjection of CRISPR/Cas9 Protein into Channel Catfish, Ictalurus punctatus, Embryos for Gene Editing
16:08

Microinjection of CRISPR/Cas9 Protein into Channel Catfish, Ictalurus punctatus, Embryos for Gene Editing

Published on: January 20, 2018

14.3K

科学分野:

  • 遺伝学 遺伝学とは
  • 微生物学 微生物学とは
  • バイオインフォマティックス

背景:

  • カノニカル遺伝子コードは,生涯にわたって高度に保存されていると考えられています.
  • 標準的な遺伝子コードへの例外は,以前はほとんど記録されていませんでした.

研究 の 目的:

  • 環境生物における遺伝子コードの変異の流行と範囲を調査する.
  • メタゲノムデータにおけるストップコドン再配分の事例を特定する.

主な方法:

  • メタゲノムデータの5.6兆塩基対の分析.
  • ストップコドン再配分イベント,特にオパールと珀のコドンについてスキャンします.
  • 1700以上の環境サンプルを検査した.

主要な成果:

  • 環境サンプルの大部分は,再コーディングイベントを示した.
  • 広範なオパールとアンバーのストップコドン再配分が細菌菌体で観察されました.
  • オパールストップコドン再配分は,バクテリアでも検出されました.

結論:

  • バクテリオファージは,異なる遺伝子コードを持つ宿主を感染させ,敵対関係につながります.
  • 自然界にある遺伝子コードの多様性は,合成生物学について慎重に検討する必要がある.
  • 遺伝子コードが変更された人工生物は,意図せぬ遺伝子交換を防ぐために,自然の多様性を考慮する必要があります.