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An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice
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TRPV1の痛み受容体は,神経ペプチド信号伝達によって長寿と代謝を調節する

Céline E Riera1, Mark O Huising2, Patricia Follett3

  • 1Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; The Glenn Center for Aging Research, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Cell
|May 27, 2014
PubMed
まとめ

痛み受容体 (TRPV1) が欠けているマウスは長生きし,若々しい代謝を維持します. この長寿は,CGRPの減少,インスリン分泌の改善,代謝の健康に関連しており,痛み受容体とCGRP経路が老化に影響することを示唆しています.

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