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Updated: Apr 29, 2026

Extracting Modified Microtubules from Mammalian Cells to Study Microtubule-Protein Complexes by Cryo-Electron Microscopy
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高解像度のマイクロチューブル構造は,GTPの水解時にαβ-チューブリンにおける構造的移行を明らかにする

Gregory M Alushin1, Gabriel C Lander2, Elizabeth H Kellogg3

  • 1Biophysics Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|May 27, 2014
PubMed
まとめ

細胞機能に不可欠な微小管の動的不安定性は,GTPの水解によって引き起こされます. 抗がん剤タクソルは,これらの水解によって引き起こされる形状の変化を阻害することによってマイクロチューブルを安定させ,重要な構造的洞察を明らかにします.

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Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy07:20

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