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Updated: Mar 18, 2026

A Method to Study de novo Formation of Chromatin Domains
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A Method to Study de novo Formation of Chromatin Domains

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変異型PRC1の複合体依存型H2A普遍化は,PRC2の採用とポリコンブドメインの形成を促す

Neil P Blackledge1, Anca M Farcas1, Takashi Kondo2

  • 1Laboratory of Chromatin Biology and Transcription, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK.

Cell
|May 27, 2014
PubMed
まとめ

H2AK119ub1のポリコンブ抑制複合体1 (PRC1) 改変により,ポリコンブ抑制複合体2 (PRC2) が遺伝子静止を開始する. このPRC1に依存するメカニズムは,ポリコンブドメイン形成と胚の発達に不可欠です.

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