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Cntnap4は,GABAergicとdopaminergicのシナプス伝送に差異的に貢献しています

T Karayannis, E Au, J C Patel

    Nature
    |May 30, 2014
    PubMed
    まとめ

    コンタクトインに関連したタンパク質類似4 (Cntnap4) 損失は,阻害性ニューロン出力を低下させ,矛盾的にドーパミンの放出量を増加させます. マウスにおけるこのシナプス機能障害は,精神疾患の治療目標を示唆している.

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