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Updated: Apr 29, 2026

Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
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Combined DNA-RNA Fluorescent In situ Hybridization FISH to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

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RLIMは,マウスの胚性エピブラストにおけるX染色体の不活性化に欠かせない

JongDae Shin1, Mary C Wallingford2, Judith Gallant3

  • 1Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS), Worcester, Massachusetts 01605, USA.

Nature
|May 30, 2014
PubMed
まとめ

ユビキチンリガゼRLIMは,雌マウスのランダムなX染色体不活性化 (rXCI) に必要不可欠ではありません. RLIMが欠けている胚細胞はXCIを受け,XistがRLIMから独立したメカニズムで活性化することを示す.

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