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Updated: Apr 28, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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BRCA2はRループの蓄積を防止し,TREX-2 mRNAの輸出因子PCID2と関連しています

Vaibhav Bhatia1, Sonia I Barroso1, María L García-Rubio1

  • 1Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla, Avenida Américo Vespucio s/n, 41092 Seville, Spain.

Nature
|June 5, 2014
PubMed
まとめ

老化と癌に関連したゲノム不安定は,R-ループと呼ばれるRNA-DNAハイブリッドから生じる可能性があります. TREX-2複合体は,この不安定性を防止し,BRCA2はRループを処理し,がんに関連したゲノム不安定性におけるその役割を強調する.

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