Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Long-term Potentiation01:35

Long-term Potentiation

51.5K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.5K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Long-term Depression01:05

Long-term Depression

27.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.2K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.8K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.8K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

The Lateral Habenula to Ventral Tegmental Area Pathway is Required for Aversive Learning and Defensive Behaviors.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Review: "The Disappointment Dilemma: Short- and Long-Term Learning From Negative Outcomes".

The European journal of neuroscience·2026
Same author

How ketamine works: An actionable hypothesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Transcriptional Profiling of the Cortico-Accumbal Pathway Reveals Sex-Specific Alterations Underlying Stress Susceptibility.

Biological psychiatry·2025
Same author

Dual-color optical activation and suppression of neurons with high temporal precision.

eLife·2025
Same author

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

Cells·2024
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
Same journal

China boosts prestigious grants for young scientists - will it ease competition?

Nature·2026
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: Apr 28, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

13.7K

LTDとLTPでメモリを設計する.

Sadegh Nabavi1, Rocky Fox1, Christophe D Proulx2

  • 11] Center for Neural Circuits and Behavior, Department of Neuroscience and Section of Neurobiology, University of California at San Diego, California 92093, USA [2].

Nature
|June 5, 2014
PubMed
まとめ
この要約は機械生成です。

科学者は,長期抑うつ (LTD) が恐怖の記憶を無効化し,長期増強 (LTP) が恐怖の記憶を活性化することを示しています. この研究は,シナプス可塑性を記憶と結びつける因果的な証拠を提供します.

さらに関連する動画

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K

関連する実験動画

Last Updated: Apr 28, 2026

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice
11:13

Long-term Potentiation of Perforant Pathway-dentate Gyrus Synapse in Freely Behaving Mice

Published on: November 29, 2013

13.7K
Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
09:39

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation

Published on: June 26, 2013

26.7K
Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
07:17

Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

Published on: June 23, 2022

2.6K

科学分野:

  • 神経科学は神経科学である.
  • 細胞生物学 細胞生物学
  • 記憶の研究 記憶の研究

背景:

  • 記憶のエンコーディングは,シナプス可塑性,特に長期増強 (LTP) と長期うつ病 (LTD) を含むと仮定されています.
  • これらのシナプス機構と記憶の間の直接的な因果関係を確立することは,神経科学における重要な課題であり続けています.

研究 の 目的:

  • 関連恐怖記憶の不活性化および再活性化におけるLTPとLTDの因果的役割を調査する.
  • 標的型シナプス改変を通じて,メモリリコールを直接操作することを実証する.

主な方法:

  • オプトジェネティクスを活用して,動物モデルで桃体を標的とした聴覚入力を刺激しました.
  • 足のショックに関連した恐怖記憶を無効にするためのLTDコンディショニングを適用しました.
  • 不活性化された恐怖記憶を再活性化するために,LTPコンディショニングを適用した.

主要な成果:

  • オプト遺伝学的に誘発されたLTDは,条件付き恐怖記憶を無効化することに成功しました.
  • その後,光遺伝学的に誘発されたLTPは,以前に不活性化された恐怖記憶を再活性化しました.
  • シナプス性可塑性操作による記憶状態 (無活性化/再活性化) の正確な制御を実証した.

結論:

  • 長期うつ病 (LTD) と長期増強 (LTP) を,記憶の無活性化と再活性化のメカニズムと結びつける強力な因果的証拠を提供します.
  • シナプス性可塑性は,記憶形成とリコールのための基本的な細胞基盤であるという仮説を支持する.
  • 記憶関連の障害を理解し,潜在的に治療するための標的型シナプス調節の可能性を強調しています.