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Updated: Apr 28, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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心筋線維細胞のグリコゲン合成酵素キナーゼ-3βは,心不全性心臓における心室の改造と機能不全を調節する

Hind Lal1, Firdos Ahmad1, Jibin Zhou1

  • 1From the Center for Translational Medicine (H.L., F.A., J.Z., J.E.U., R.J.V., Y.G., E.G., T.F.), Department of Clinical Sciences (D.Y.), and Section of Cardiology (E.J.T., T.F.), Temple University School of Medicine, Philadelphia, PA; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada (J.W.); and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN (H.L., F.A., Y.G., T.F.).

Circulation
|June 6, 2014
PubMed
まとめ

グリコゲン合成キナーゼ-3β (GSK-3β) 抑制は,ミオフィブロブラストとTGF-β1/SMAD-3シグナル伝達を活性化することによって,心筋線維症を促進します. ターゲティングGSK-3βは,心筋線維性疾患の治療に役立ちます.

キーワード:
線維芽細胞 (Fibroblasts) が形成されている.線維症が発症しています.グリコーゲンシンサゼキナーゼ3ββ3ββ3β3β3β3β3β3β3β3β3β3β3β3β3β3β3ハイパルトロフィー・ハイパートロフィー心筋梗塞 (心筋梗塞) による心筋梗塞.

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