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Updated: Apr 28, 2026

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
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A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

Published on: November 28, 2014

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細胞毒性細胞は,グラヌリシン媒介によるグラン酵素の投与によって細胞内細菌を殺害する

Michael Walch1, Farokh Dotiwala1, Sachin Mulik1

  • 1Cellular and Molecular Medicine Program, Boston Children's Hospital, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.

Cell
|June 7, 2014
PubMed
まとめ

殺人細胞は,グラヌリシンを使用して,細菌にグラン酵素を送り込み,不可欠なタンパク質を損傷し,活性酸素種 (ROS) を生成することによって細胞死を誘発します. これは,新しい抗微生物防御機構を明らかにしています.

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