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Updated: Apr 28, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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ヒッポの経路活動は,肝細胞の運命を左右する

Dean Yimlamai1, Constantina Christodoulou2, Giorgio G Galli2

  • 1The Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Division of Gastroenterology and Nutrition, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Cell
|June 7, 2014
PubMed
まとめ

ヒッポシグナル伝達経路は,成熟した肝細胞の同一性を維持する. それを無効化すると,成人の肝細胞が原始細胞のような細胞に戻り,可塑性と肝臓再生への影響を明らかにします.

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Cell Specific Gene Expression01:58

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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