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歴史的な偶然性と,グルココルチコイド受容体の進化におけるその生体物理的根拠

Michael J Harms1, Joseph W Thornton2

  • 11] Institute of Molecular Biology and Department of Chemistry &Biochemistry, University of Oregon, Eugene, Oregon 97403, USA [2] Departments of Human Genetics and Ecology &Evolution, University of Chicago, Chicago, Illinois 60637, USA.

Nature
|June 17, 2014
PubMed
まとめ

進化の歴史は,珍しい偶然の出来事によって形作られました. 祖先のグルココルチコイド受容体 (GR) の機能変化に必要な特定のタンパク質変異は,生理学的制約のために例外的にまれでした.

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