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Updated: Apr 28, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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CBP/p300ブロモドメインのための小分子リガンドの発見と最適化

Duncan A Hay1, Oleg Fedorov, Sarah Martin

  • 1Department of Chemistry, University of Oxford , South Parks Road, Oxford OX1 3TA, U.K.

Journal of the American Chemical Society
|June 20, 2014
PubMed
まとめ

研究者らはCBP/p300ブロモドメインを標的とした強力で選択的な小分子阻害剤を開発した. これらの新しいリガンドは,CBP/p300の役割を研究し,それらを治療標的として検証する見通しを示しています.

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