関連する実験動画

Updated: Apr 27, 2026

A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators
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A High-throughput-compatible FRET-based Platform for Identification and Characterization of Botulinum Neurotoxin Light Chain Modulators

Published on: December 27, 2013

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ボツリヌム神経毒素A複合体によるE-カデリンの粘着の破壊の分子基礎

Kwangkook Lee1, Xiaofen Zhong2, Shenyan Gu1

  • 1Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA.

Science (New York, N.Y.)
|June 21, 2014
PubMed
まとめ

ボトリヌム神経毒素 (BoNT/A) は,E-カデリンと炭水化物を結合するヘマグルチニン (HA) を使用して腸壁を横切ります. この相互作用は細胞の結合を損なうため,毒素の吸収と経口毒性を可能にします.

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