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Updated: Apr 27, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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グルココルチコイド受容体の機能は,Hsp90とHsp70のチャペロンサイクルの協調作用によって調節されます

Elaine Kirschke1, Devrishi Goswami2, Daniel Southworth1

  • 1Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

Cell
|June 21, 2014
PubMed
まとめ

分子チャペロンであるHsp70とHsp90は,グルココルチコイド受容体 (GR) の機能を調節する. Hsp70はGRを無効化し,コチャペロンを含むHsp90は,その結合結合能力と安定性を回復する.

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