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Chemical Triphosphorylation of Oligonucleotides
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モリボドプテリンのバイオシンセシス: 2'-デオキシGTPと2'-クロロGTPを基質アナログとして使用して,MoaA触媒反応のための中間物質のトラップ

Angad P Mehta1, Sameh H Abdelwahed, Hui Xu

  • 1Department of Chemistry, Texas A & M University , College Station, Texas 77843, United States.

Journal of the American Chemical Society
|June 24, 2014
PubMed
まとめ

この研究は,モリボドプテリンの生物合成における,過激なS-アデノシルメチオニン酵素MoaAのメカニズムを詳細に説明しています. 研究者は,重要な中間物質を捕まえるために化学的探査機を使用し,グアノシン-5'-トリホスファートの再配置を解明しました.

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