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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
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細胞内タンパク質に対する細胞浸透性バイサイクルペプチド阻害剤

Wenlong Lian1, Bisheng Jiang, Ziqing Qian

  • 1Department of Chemistry and Biochemistry, The Ohio State University , 484 West 12th Avenue, Columbus, Ohio 43210, United States.

Journal of the American Chemical Society
|June 28, 2014
PubMed
まとめ

サイクルペプチドは,細胞に浸透するペプチドと融合させ,バイサイクルペプチドを生成することによって,細胞に浸透させることができます. この戦略は,強力な酵素阻害剤を生み出し,その治療的可能性を高めます.

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