PTP1bは,血管内皮細胞における血管内皮成長因子シグナル伝達の生理学的調節体である

Anthony A Lanahan¹, Diana Lech¹, Alexandre Dubrac¹

¹From the Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine (A.A.L., D.L., A.D., J.Z., Z.W.Z., A.E., M.S.) and the Department of Cell Biology (M.S.), Yale University School of Medicine, New Haven, CT.

Circulation

|July 2, 2014

まとめ

フォスファタゼPTP1bは血管形成を調節する. 内皮細胞内のPTP1bを除去すると,血管内皮成長因子受容体-2 (VEGFR2) のシグナル伝達が強化され,血管新生と動脈新生が促進されます.

科学分野:

血管生物学血管生物学とは
分子シグナル伝達です.
再生医学は再生医学である.

背景:

血管内皮成長因子受容体-2 (VEGFR2) 信号伝達は,血管樹の形成を制御する.
VEGFR2の内皮細胞の密輸は,その活動に影響を与えます.
フォスファタゼPTP1b (PTP1b) は,VEGFR2の内皮の密輸に関与しています.

研究の目的:

内皮のVEGFR2シグナル伝達におけるPTP1bの役割を定義する.
PTP1bが血管新生と動脈新生を調節する役割を調査する.

主な方法:

PTP1b.の内皮特異的なデリエーションを持つマウスを生成した.
VEGFシグナル伝達,血管新生,動脈形成をインビトロおよびインビボで評価した.
網膜血管新生,マトリゲルインプラント,後肢缺血モデルを使用した.

主要な成果:

PTP1bのノックアウト内皮細胞は,VEGFに依存したシグナル伝達,発芽,移動,増殖が増加した.
内皮PTP1bゼロマウスは,網膜とマトリゲルの血管新生が強化され,傷の治癒が加速された.
動脈形成の増加が観察され,後肢イシュケミアモデルでは血流の回復と新血管の形成がより速くなりました.

結論:

PTP1bは,内皮のVEGFR2信号伝達の重要なレギュラーである.
PTP1bは,血管樹形成の範囲を制御する上で重要な役割を果たします.

キーワード:

PTP1bb は,PTP1bb を使っています.VEGFは,VEGFと一致している.VEGF受容体-2は,VEGF受容体-2に結合している.アンジオゲネシスアンジオゲネシス動脈形成は,動脈形成によって起こります.細胞外信号調節キナーゼは,細胞外信号調節キナーゼを

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