哺乳類における進化的指の喪失のパターニングとポストパターニングのモード
Kimberly L Cooper1, Karen E Sears2, Aysu Uygur3
11] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA. [3].
Nature
|July 4, 2014
まとめ
哺乳類における桁の縮小は,多様な発達経路を経て進化する. 細胞死を利用して指を彫刻する種もあれば,早期の四肢のパターンを変化させ,進化の可塑性を明らかにする種もあります.
科学分野:
- 発達生物学 発達生物学とは
- 進化生物学の進化生物学について
- 比較解剖学の比較解剖学について
背景:
- 桁の縮小は,カーソリウム哺乳類における一般的な進化的適応である.
- 数字の喪失を誘発する発達メカニズムは,十分に理解されていません.
研究 の 目的:
- 様々な哺乳類の種における指の喪失の基礎となる発達メカニズムを調査する.
- 肢体の発達における進化的可塑性を理解するために.
主な方法:
- ジェルボア,馬,ラクダ,豚の肢体の発達を比較した分析.
- コンドロゲネシス中の細胞死と遺伝子発現パターンの検査.
主要な成果:
- 指の喪失は,早期の四肢パターニングまたは後のコンドロゲネシス段階において発生する可能性があります.
- ジェルボア,馬,ラクダは,指の彫刻のために有意な細胞死を示しています.
- 豚の指の喪失は,細胞死が増加することなく,Ptch1のダウンレギュレーションを含む早期のパターンの変化を含みます.
結論:
- 脊椎動物の四肢の進化は,発達メカニズムにおける驚くべき可塑性を示しています.
- 形態学的収束は,特にアルティオダクティルの場合,多様な進化戦略を伴う.
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