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Updated: Apr 27, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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メチルトランスフェラーゼは,テレオシジンB生物合成におけるテルペンサイクリングを開始する

Takayoshi Awakawa1, Lihan Zhang, Toshiyuki Wakimoto

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|July 4, 2014
PubMed
まとめ

研究者らは,タンパク質キナーゼC活性化剤であるテレオシジンBバイオシンセシスの遺伝子を特定した. 新しいメチルトランスフェラーゼ (tleD) は,この経路で初めて,カチオン形成経由でテルペノイド環の閉塞を誘発する.

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