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Updated: Apr 2, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
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Associated Chromosome Trap for Identifying Long-range DNA Interactions

Published on: April 23, 2011

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コーディングおよび規制DNA要素によって採用された3D軌跡:ゲノム相互作用のファーストパスタイム

Joseph S Lucas1, Yaojun Zhang2, Olga K Dudko2

  • 1Division of Biological Sciences, Department of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|July 8, 2014
PubMed
まとめ

B細胞受容体の遺伝子セグメントは,細胞の内部環境によってランダムに移動する. 空間的拘束は,これらのDNA要素が適切な遺伝子アセンブリのために互いにどれくらい早く見つけるかに大きな影響を与えます.

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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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