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Updated: Jul 9, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

ステロイド/甲状腺ホルモン受容体の標的遺伝子の特異性の決定因子

K Umesono1, R M Evans

  • 1Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037.

Cell
|June 30, 1989
PubMed
まとめ

研究者はホルモン受容体を改変して,DNA結合特異性を変化させた. いくつかのアミノ酸の変化により,グルココルチコイド受容体はエストロゲンまたは甲状腺ホルモン受容体へと変化し,重要な構造的決定因子を明らかにした.

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