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関連する概念動画

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

162
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
162
Development of Human Microbiota01:30

Development of Human Microbiota

60
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
60
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

74
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
74
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

94
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
94
The Oral Microbiota01:27

The Oral Microbiota

87
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
87
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

52
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
52

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Updated: Apr 26, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

29.3K

微生物群の研究を行う.

Julia K Goodrich1, Sara C Di Rienzi1, Angela C Poole1

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA; Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.

Cell
|July 19, 2014
PubMed
まとめ
この要約は機械生成です。

このプライマーは,研究者がヒト微生物群の研究を設計,実行,分析する際のガイドです. これは,微生物コミュニティとその健康や病気への影響に関する理解を深めるための再現可能な研究を保証します.

さらに関連する動画

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
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Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

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Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing
08:05

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Published on: March 19, 2018

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関連する実験動画

Last Updated: Apr 26, 2026

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

29.3K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

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Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing
08:05

Guided Protocol for Fecal Microbial Characterization by 16S rRNA-Amplicon Sequencing

Published on: March 19, 2018

19.5K

科学分野:

  • 微生物学 微生物学とは
  • ゲノミクスゲノミクスとは
  • バイオインフォマティックス

背景:

  • 人間の微生物群の研究は急速に進んでおり,健康,病気,ライフスタイルに影響を及ぼしています.
  • 進歩は,厳格で再現可能な研究設計とデータ分析に依存しています.
  • 総合的な微生物群調査には,学際的な協力が不可欠です.

研究 の 目的:

  • ヒト微生物群の研究分野に入ろうとしている研究者のための基本的ガイドを提供すること.
  • マイクロバイオーム研究の設計,実行,分析に関する重要な考慮事項の概要を述べる.
  • マイクロバイオーム科学に再現可能で影響力のある貢献を促進する.

主な方法:

  • プライマーは,微生物群の研究設計のためのベストプラクティスを合成しています.
  • 実験実行とデータ処理のための重要な要因を詳細に説明しています.
  • 勧告は,微生物群データの統計分析と解釈をカバーしています.

主要な成果:

  • 堅実な微生物群の研究の計画と実施のための枠組みを提供します.
  • 潜在的な落とし穴を強調し,共通の課題に対する解決策を提供しています.
  • 信頼できる,有意義なデータを生成するために研究者に力を貸します.

結論:

  • これらの勧告を遵守すると,ヒト微生物群の研究の質と再現性が向上します.
  • このガイドは,マイクロバイオーム分野における新しい発見を促進することを目的としています.
  • それは,総合的な理解のために,多様な研究アプローチの統合をサポートします.