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Updated: Apr 26, 2026

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A20によるNLRP3炎症ゾームの負の調節は,関節炎から保護します

Lieselotte Vande Walle1,2, Nina Van Opdenbosch1,2, Peggy Jacques3

  • 1Department of Medical Protein Research, VIB, Ghent, B-9000, Belgium.

Nature
|July 22, 2014
PubMed
まとめ

新しいマウスモデルにおけるリウマチ性関節炎の病理学は,Nlrp3炎症体に依存しています. 骨髄細胞のA20遺伝子を削除すると,関節炎が引き起こされ,A20がこの疾患における炎症体の活性化の調節体として強調されます.

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