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腫瘍に由来するPTH関連のタンパク質は,脂肪組織の茶色化と癌のカシェキシアを誘発する

Serkan Kir1, James P White1, Sandra Kleiner1

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|July 22, 2014
PubMed
まとめ

腫瘍に由来する副甲状腺ホルモン関連タンパク質 (PTHrP) は,がんカシェキアにおける茶色の脂肪の活動と筋肉の消耗を誘発する. マウスのPTHrPを中和させることで,これらの効果が軽減され,患者のアウトカムを改善するための潜在的な治療目標を示唆しました.

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