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Nucleic Acid Structure01:25

Nucleic Acid Structure

8.0K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
8.0K
Nucleic Acids02:43

Nucleic Acids

40.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
40.2K
Nucleic acids02:43

Nucleic acids

149.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
149.0K
Nucleic Acids02:43

Nucleic Acids

7.2K
7.2K
Characteristics and Nomenclature of Homopolymers01:00

Characteristics and Nomenclature of Homopolymers

3.0K
Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
3.0K
Phosphodiester Linkages01:01

Phosphodiester Linkages

99.0K
Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
99.0K

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Chemical Triphosphorylation of Oligonucleotides
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ポリオリゴヌクレオチド (ポリオリゴヌクレオチド)

Carrie R James1, Anthony M Rush, Thomas Insley

  • 1Department of Chemistry and Biochemistry, University of California, San Diego , La Jolla, California 92093, United States.

Journal of the American Chemical Society
|August 1, 2014
PubMed
まとめ
この要約は機械生成です。

研究者らは,グラフト・スルー・ポリメリゼーションを用いた新しい核酸ポリマーを作り出した. これらのポリペプチド核酸 (PNA) 材料は,ナノ粒子を形成し,DNAとハイブリッド化し,バイオマテリアルの開発を進めることができます.

さらに関連する動画

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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関連する実験動画

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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科学分野:

  • ポリマー化学のポリマー化学について
  • バイオマテリアル科学 バイオマテリアル科学
  • 核酸化学 核酸化学について

背景:

  • 核酸ベースのポリマーは,高度なアプリケーションにユニークな特性を提供します.
  • 核酸単体に対する効率的なポリメリゼーション方法の開発は極めて重要です.
  • ペプチド核酸 (PNA) は,診断と治療の潜在能力を有するDNAの模倣物です.

研究 の 目的:

  • ポリ ((オリゴヌクレオチド) ブラシポリマーとアンフィフィリックブラシコポリマーを合成するために.
  • ポリ-PNAナノ粒子の形成を調査する.
  • これらのPNAナノ構造とDNAのハイブリッド化能力を調査する.

主な方法:

  • 核酸モノメアの移植によるポリメリゼーション.
  • ルテニウムベースのイニシアターを使用したPNA-ノルボニル単体によるリング開きメタテシスポリメリゼーション (ROMP).
  • アンフィフィリックブロックコポリマーをナノ粒子に自己組み立て.
  • 単一鎖DNA (ssDNA) によるハイブリデーションアッセイ.

主要な成果:

  • ポリ (オリゴヌクレオチド) ブラシポリマーとアンフィフィリックブラシコポリマーの製造に成功しました.
  • ROMPによるポリ-PNAの合成.
  • アンフィフィリックブロックコポリマーからポリ-PNAナノ粒子の形成.
  • 補完的なssDNAを持つポリ-PNAナノ粒子のハイブリッド化が実証されました.

結論:

  • ポリ (オリゴヌクレオチド) ブラシポリマーとコポリマーを効率的に合成することができます.
  • PNAベースのナノ粒子は形成され,特定のDNA結合を示すことができます.
  • この研究は,分子認識と診断におけるPNAベースのナノ構造の基礎となる.