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Updated: Apr 26, 2026

Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells

Published on: May 1, 2020

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RNA G四重複体は,がんにおけるeIF4Aに依存した腫瘍遺伝子の翻訳を引き起こします

Andrew L Wolfe1, Kamini Singh2, Yi Zhong3

  • 11] Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, USA [3].

Nature
|August 1, 2014
PubMed
まとめ

ユカリオット発現因子4A (eIF4A) のRNAヘリカーゼは,がんにおける腫瘍遺伝子の発現を誘導する. 抗癌化合物であるシルベストロールは,このメカニズムを標的とし,白血病やその他の癌の治療の可能性を提供します.

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