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Updated: Apr 26, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells

Published on: May 16, 2017

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C9orf72リピートによってコードされたポリディペプチドは,核細胞と結合し,RNA生殖を阻害し,細胞を殺す

Ilmin Kwon1, Siheng Xiang1, Masato Kato1

  • 1Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA.

Science (New York, N.Y.)
|August 2, 2014
PubMed
まとめ

セルリン:アルギニン (SR) ドメインを持つRNA結合タンパク質は,hnRNPA2ヒドロゲルと結合する. CLK1/2によるリン酸化は結合を逆転させ,C9orf72疾患ペプチドはRNAバイオゲネシスを破壊することで細胞死を引き起こす.

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