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Updated: Apr 26, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

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構造生物学 構造生物学とは エシェリキヤ大腸菌からのCRISPRRNA誘導監視複合体の結晶構造

Ryan N Jackson1, Sarah M Golden1, Paul B G van Erp1

  • 1Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.

Science (New York, N.Y.)
|August 9, 2014
PubMed
まとめ

抗ウイルス防御 (カスケード) 構造のためのCRISPRに関連した複合体は,Escherichia coliのようなバクテリアがウイルスと戦うためにRNA誘導システムを使用する方法を示しています. このバクテリアの免疫システムは,

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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