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関連する概念動画

2D NMR: Overview of Homonuclear Correlation Techniques01:16

2D NMR: Overview of Homonuclear Correlation Techniques

801
Homonuclear correlation spectroscopy (COSY) is a powerful technique used in Nuclear Magnetic Resonance (NMR) spectroscopy to study the correlations between nuclei of the same type within a molecule. It provides information about scalar couplings between adjacent nuclei, which helps determine connectivity and structural information. There are several COSY variants, each with its unique strengths and experimental parameters.
COSY90 is the standard two-dimensional (2D) COSY experiment that...
801
2D NMR: Homonuclear Correlation Spectroscopy (COSY)01:06

2D NMR: Homonuclear Correlation Spectroscopy (COSY)

1.9K
Homonuclear correlation spectroscopy, or COSY, is a 2-dimensional NMR technique that provides information about coupled protons. Typically, the geminal and vicinal coupling are observed. For example, consider the COSY spectrum of ethyl acetate, where its 1D proton NMR spectrum is plotted along the vertical and horizontal axes with their corresponding chemical shift scale. Three spots on the diagonal corresponding to the three peaks in the 1D proton spectrum are called diagonal peaks. The COSY...
1.9K
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)01:19

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

1.3K
Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...
1.3K
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

901
Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
901
NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

2.0K
NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
2.0K
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

990
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
990

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関連する実験動画

Updated: Apr 26, 2026

Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics
13:16

Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics

Published on: July 31, 2021

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超高解像度トータル相関性NMRスペクトロスコピー

Mohammadali Foroozandeh1, Ralph W Adams, Mathias Nilsson

  • 1School of Chemistry, University of Manchester , Oxford Road, Manchester M13 9PL, U.K.

Journal of the American Chemical Society
|August 12, 2014
PubMed
まとめ

PSYCHEと呼ばれる新しい方法は,スペクトルの解像度と感度を改善することによって,核磁共鳴 (NMR) スペクトロスコピーを強化します. このテクニックは,TOCSY実験に適用され,構造分析と自動解明を簡素化します.

科学分野:

  • 核磁共振 (NMR) スペクトロスコピー
  • 有機化学 オーガニック・ケミストリー
  • 構造生物学 構造生物学とは

背景:

  • 高解像度NMRスペクトロスコピーは,分子構造の決定に不可欠です.
  • 純粋シフトNMR技術はスペクトルの解像度を向上させますが,しばしば感度が低下します.
  • 純粋シフトNMRの以前の方法は,感度とスペクトル純度の制限があります.

研究 の 目的:

  • 核オーバーハウザー効果スペクトロスコピー (TOCSY) 実験におけるPSYCHEメソッドの性能を評価する.
  • PSYCHEがスペクトル解像度,感度,信号対ノイズ比に与える影響を評価する.
  • PSYCHE-TOCSYの有用性を,単純化されたスペクトル分析と構造解明のために実証する.

主な方法:

  • PSYCHE (Pure Shift Yields Chemical shift Evolution) テクニックをTOCSY NMR実験に応用する.TOCSY NMR実験に応用する.
  • PSYCHE-TOCSY.と組み合わせた共変数処理を使用しています.
  • 高解像度,純粋シフトTOCSYスペクトルの取得と分析.

主要な成果:

  • PSYCHEは,通常,純粋シフトNMRに関連した感受性喪失を大幅に軽減します.

さらに関連する動画

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

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Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization
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Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization

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Last Updated: Apr 26, 2026

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Pure Shift Nuclear Magnetic Resonance: a New Tool for Plant Metabolomics

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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
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Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization
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Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization

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  • PSYCHE-TOCSYスペクトルは,改善された解像度,スペクトルの純度,および強いカップリングに対する耐性を示す.
  • 結果として得られる純粋な化学シフト相関マップは,スペクトルの解釈を簡素化します.

    • 結論:

    • PSYCHEは,高品質で高解像度の純粋シフトTOCSYスペクトルを取得するための非常に効果的な方法です.
    • この技術は,既存の純粋シフト方法よりも,特に感度において,大幅な改善をもたらします.
    • PSYCHE-TOCSYスペクトルは,手動および自動分子構造の解明の両方を大いに容易にすると予想されています.