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Updated: Apr 25, 2026

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
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Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

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RIG-I媒介による5'-二リン酸塩を含むRNAの認識による抗ウイルス免疫

Delphine Goubau1, Martin Schlee2, Safia Deddouche1

  • 1Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.

Nature
|August 15, 2014
PubMed
まとめ

RIG-I (レチノ酸誘導性遺伝子I) は,5'-二リン酸 (5'pp) を含むウイルスRNAを認識し,先天的免疫におけるその役割を拡大する. この発見は,細胞がウイルス侵入者を自己細胞と区別する方法の理解を深める.

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