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Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
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グルタミン酸受容体の活性化と無敏感化の構造的メカニズム

Joel R Meyerson1, Janesh Kumar2, Sagar Chittori2

  • 1Laboratory of Cell Biology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892, USA.

Nature
|August 15, 2014
PubMed
まとめ

構造的な研究は,AMPAとカイナート受容体のゲーティングがコルクスクリーブの動きとドメインの再編成をどのように含むかを明らかにします. これらの発見は,刺激性神経伝達のためのイオンチャネル機能の重要なステップを説明します.

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