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Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
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インターリューキン-22は代謝障害を緩和し,糖尿病における粘膜免疫を回復します
Xiaoting Wang1, Naruhisa Ota1, Paolo Manzanillo2
11] Department of Immunology, Genentech, South San Francisco, California 94080, USA [2].
Nature
|August 15, 2014
まとめ
インターリューキン-22 (IL-22) は,腸の健康と代謝に重要な役割を果たします. IL-22機能の回復は,肥満やインスリン抵抗性などの代謝障害を逆転させ,その治療的可能性を強調することができます.
科学分野:
- 免疫学 免疫学とは
- メタボリック障害 メタボリック障害
- マイクロバイオーム研究
背景:
- 変化した腸内微生物群は代謝障害 (肥満,糖尿病,心血管疾患) と関連しています.
- 粘膜壁の整合性が損なわれると,内毒性および慢性炎症を引き起こし,代謝症候群を促進します.
- インターリューキン-22 (IL-22) は,腸の免疫と粘膜壁の機能に不可欠です.
研究 の 目的:
- 代謝障害におけるIL-22の役割を調査する.
- 代謝疾患におけるIL-22経路の治療の可能性を調査する.
主な方法:
- Citrobacter rodentiumで挑戦された肥満マウスのIL-22誘導を研究しました.
- IL-22受容体が欠乏したマウスと遺伝子的に肥満のマウス (db/db) で高脂肪食を摂取した代謝パラメータの評価.
- 肥満マウスモデルに外因的なIL-22を投与した.
主要な成果:
- 肥満マウスではIL-22誘導が損なわれ,感染症に対する腸内防御が損なわれた.
- IL-22欠乏症は,高脂肪食を摂ったマウスの代謝障害を悪化させた.
- 外因的なIL-22投与は,肥満マウスの高血糖症,インスリン抵抗性,および改善された腸の障壁機能を逆転させた.
結論:
- IL-22シグナル伝達の障害は,代謝機能障害に寄与する.
- IL-22の投与は,インスリン感受性の向上と炎症の減少を含む,重要な代謝効果を示しています.
- IL-22経路は,代謝疾患における有望な治療標的である.
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