慢性閉塞性肺疾患の危険因子と早期の起源
Dirkje S Postma1, Andrew Bush2, Maarten van den Berge1
1Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Lancet (London, England)
|August 16, 2014
まとめ
喫煙だけでなく,人生の初期に被曝したものは,慢性閉塞性肺疾患 (COPD) の発症に大きく影響します. これらの多様な危険因子を理解することは,この異質な肺疾患の管理に不可欠です.
科学分野:
- 肺内医学 肺内医学 肺内医学
- 環境衛生 環境衛生 環境衛生
- 発達小児科 発達小児科
背景:
- 慢性阻害性肺疾患 (COPD) は,主に喫煙に関連した,世界的な主要な健康問題です.
- 中年期に臨床的に明らかになる一方で,COPDの起源は,人生の初期に暴露されたものに遡ります.
- 現在のCOPDの診断は,疾患の異質性を無視して,肺機能に大きく依存しています.
研究 の 目的:
- 生命の初期にCOPDの危険因子に関する証拠をレビューする.
- 生命のさまざまな段階とCOPDのフェノタイプにおける危険因子を調査する.
- COPDの発症の異質性を強調するために.
主な方法:
- COPDのリスク因子に関する研究の文献レビュー.
- 産前期および幼児期における証拠の分析.
- 様々なCOPD現象型に寄与する危険因子の検討.
主要な成果:
- 産前および幼少期の環境曝露は,COPDに大きく寄与しています.
- 異なるリスクファクターは,異なるCOPD現象型に影響を与えます.
- 生命の初期に起因する要因は,病気のプロセスを開始し,生命の後の臨床的表れにつながります.
結論:
- COPDの発症は多因性であり,生命の初期に重大な影響を及ぼします.
- 生命の初期に発生する危険因子に対処することは,COPDの予防と管理のための新しい道を開く可能性があります.
- COPDの異質性を認識することは,ターゲットを絞った介入に不可欠です.
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