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関連する概念動画

Parental Care00:55

Parental Care

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Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
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Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Fertilization01:38

Fertilization

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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Relationship with Parents: Attachment01:28

Relationship with Parents: Attachment

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Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
371
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Imprinting01:22

Imprinting

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Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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子育ては受胎前から始まっています.

Michelle Lane1, Rebecca L Robker1, Sarah A Robertson2

  • 1The Robinson Research Institute and School of Paediatrics and Reproductive Health, The University of Adelaide, Level 3, Medical School, South Adelaide, SA, 5005 Australia.

Science (New York, N.Y.)
|August 16, 2014
PubMed
まとめ
この要約は機械生成です。

親の年齢と環境的曝露は,ゲノムおよび表遺伝子情報を通して胚の発達に影響を与えます. DNAメチル化とノンコーディングRNAを含むこれらの要因は,受胎前に始まり,子供の生涯の健康に影響を与えます.

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科学分野:

  • 生殖生物学 生殖生物学
  • 発達生物学 発達生物学について
  • エピジェネティクス エピジェネティクス

背景:

  • 受精は,親の年齢と環境の影響を受け,胚のゲノム設計図を確立します.
  • 親の経歴と経験は,DNA配列を超えたエピジェノミック情報を通して子孫に影響を与えます.

研究 の 目的:

  • 胚および胎児の発達のプログラミングにおける親のエピジェノミック情報の役割を調査する.
  • 世代を超えたエピジェネティック効果が,子どもの生涯の健康状態にどのように影響するかを理解する.

主な方法:

  • 子孫のエピジェネティクスに対する親の影響に関する最近の研究のレビュー.
  • 精子および卵細胞のサイトシンメチル化,クロマチンのパターニング,ノンコーディングRNA,ミトコンドリアの変動の分析.

主要な成果:

  • メチル化および非コーディングRNAを含む親の表遺伝的要因は,胚に伝播されます.
  • これらの世代を超えたエピジェネティック効果は,受胎条件と相互作用して,プログラム開発を可能にします.

結論:

  • 親のエピジェノミック情報は胎児の発達と生涯の健康に大きな影響を与えます.
  • 生物学的な育児は受胎前に始まり,胎児の発達に関する伝統的な概念に挑戦します.