早期出産:一つの症候群,多くの原因

Roberto Romero¹, Sudhansu K Dey², Susan J Fisher³

¹Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD, Wayne State University/the Detroit Medical Center, Detroit, MI, USA. Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA. Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA. romeror@mail.nih.gov.

Science (New York, N.Y.)

|August 16, 2014

まとめ

幼児死亡の主な原因である早産は,感染症や免疫の問題などの複雑な原因から生じる. プロゲストゲン治療は,リスクの高い妊娠における予防への希望を提供します.

科学分野:

生殖生物学生殖生物学
妊産婦と胎児の医学について
ネオナタロジーの新生児科

背景:

早期出産は,妊娠の5~18%に影響を与え,乳児の罹病率と死亡率を大幅に引き起こす.
spontaneous preterm labor (自発的早産) は,早産の70%を占め,予防と治療において複雑な課題を提示しています.

研究の目的:

早期出産の根底にあるメカニズムに関する現在の知識を要約する.
胎内感染症,果樹葉老化,母胎耐性障害の理解における最近の進歩をレビューする.

主な方法:

文献レビューと,早産のメカニズムに関する既存の研究の合成.
胎内感染症,葉老化,免疫耐性に関するデータの分析.

主要な成果:

spontaneous preterm laborに寄与する主要な病理学的プロセスを特定しました.
胎内感染,乳頭老化,早産における母胎耐性の役割を強調した.

結論:

プロゲストゲン療法では,特定の患者グループにおける早産の予防に有望であることが示されています.
早期出産の複雑さを解明し,幼児の成果を改善するために,さらなる研究投資が不可欠です.

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