人間のZFX遺伝子によって暗号化された代替的同位体を持つ仮転写活性化剤である
A Schneider-Gädicke1, P Beer-Romero, L G Brown
1Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
Nature
|December 7, 1989
まとめ
ZFX遺伝子は,Y-リンクされたZFY遺伝子に似ているが,ヒトの性別決定に役割を果たす可能性がある. 異なった機能領域を持つ転写活性化タンパク質をコードし,発達における多様な役割を示唆しています.
科学分野:
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
- 発達生物学 発達生物学について
背景:
- Y染色体にあるZFY遺伝子は,ヒトの性別決定に関与しています.
- X染色体上のZFX遺伝子は,ZFYと類似性を共有し,X不活性化から逃れることができる.
- ZFYとZFXは,共通の祖先の遺伝子から進化した可能性が高い.
研究 の 目的:
- ZFX遺伝子のタンパク質産物を特徴付けるために.
- 性別決定におけるZFXの潜在的な役割を調査する.
- ZFXタンパク質イソフォームの機能的影響を調査する.
主な方法:
- 補完的なDNA (cDNA) の分析
- タンパク質ドメイン分析.
- 代替スプライシングの調査.
主要な成果:
- ZFXは,酸性アミノ端末ドメイン,核定位信号,亜鉛指ドメインを持つタンパク質をコードします.
- これらの特徴は,ZFY.に似たトランスクリプション活性化剤の特徴です.
- 代替スプライシングは,酸性ドメインの長さによって異なる575および804アミノ酸のZFX同型を生成します.
結論:
- ZFXタンパク質は,転写活性化剤に特有の特徴を持っています.
- ZFX遺伝子は,ZFYに類似して,性別決定に機能する可能性があります.
- 代替スプライシングは,機能的に異なるZFXタンパク質イソフォームを生成します.
さらに関連する動画
関連する概念動画
Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Eukaryotic Transcription Activators
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
General Transcription Factors
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Master Transcription Regulators
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...


