関連する実験動画

Updated: Apr 25, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

トリグリセリドと心血管疾患

Børge G Nordestgaard¹, Anette Varbo¹

¹Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Lancet (London, England)

|August 19, 2014

まとめ

トリグリセリドの値上昇は,心血管疾患と死亡率の重要な危険因子としてますます認識されています. 新しいトリグリセリドを下げる薬剤と進行中の試験は,その心臓血管の利点を確認することを目指しています.

科学分野:

心血管医学心血管医学
脂質代謝についてです.
薬理学薬理学とは

背景:

臨床的焦点は,LDLコレステロールとHDLコレステロールからトリグリセリドに移行しました.
遺伝学的および疫学的証拠は,トリグリセリド,残留コレステロール,およびトリグリセリドに富んだリポタンパク質を心血管疾患 (CVD) の危険因子として強調しています.
低HDLコレステロールは,以前考えられていたほど,心血管疾患の原因ではないかもしれません.

研究の目的:

心血管疾患におけるトリグリセリドの役割に関する現在の理解をレビューする.
トリグリセリド管理における新たな証拠と薬物開発の影響を議論する.

主な方法:

遺伝子研究とランダム化制御試験のレビュー.
トリグリセリド値と心血管リスクに関する疫学データの分析.
トリグリセリドを下げる現在の治療法と新興治療法の議論.

主要な成果:

2〜10mmol/Lのトリグリセリド濃度は,心血管疾患のリスクの増加と関連しています.
トリグリセリド濃度>10 mmol/Lは,急性炎および潜在的にCVDのリスクを高めます.
ランダム化試験におけるトリグリセリドの減少による心血管上の利点を支持する証拠は限られているが,新しいものである.

結論:

心血管疾患の重要な要因としてトリグリセリドに対する新たな関心があります.
新しいトリグリセリドを下げる薬が開発されており,大規模な試験が進行中です.
トリグリセリド減少の心臓血管上の利点に関する決定的な証拠は,現在進行中の研究から予想されます.

関連する概念動画

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Lipids: Dietary Sources and Requirements

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Structure of Lipids

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...