ヘテロメタリックMn/Feコファクターの電子構造の柔軟性:R2loxとR2cタンパク質
Hannah S Shafaat1, Julia J Griese, Dimitrios A Pantazis
1Max-Planck-Institut für Chemische Energiekonversion , Stiftstrasse 34-36, Mülheim an der Ruhr D-45470, Germany.
Journal of the American Chemical Society
|August 26, 2014
まとめ
研究者は,R2lox酸化酵素におけるMn/Fe共因子を研究し,それが光活性であることを発見した. 光に曝露すると,Mn (III) イオンが変化する.
科学分野:
- バイオケミストリー バイオケミストリー
- バイオ・オーガニック化学 バイオ・オーガニック化学
- スペクトロスコーピーは,スペクトロスコーピーを用います.
背景:
- R2lox酸化酵素には,新しいMn/Fe共因子が含まれています.
- R2loxはリボヌクレオチド還元酵素R2cと同質性を共有しているが,機能は異なる.
研究 の 目的:
- R2lox.におけるMn/Fe共因子の電子構造を解明する.
- R2loxコファクターの光活性と構造変化を調査する.
主な方法:
- 多周波電子パラマグネット共振 (EPR) とパルス技術.
- 密度関数理論 (DFT) による計算.
主要な成果:
- R2loxコファクターは,反鉄磁気結合したMn (III) /Fe (III) ダイマーである.
- 77Kでの光活性化により,不安定なR2loxPhoto状態が形成されます.
- Mn(III) 場所の幾何学と電子状態の変化は,超細度の軸の方向転換によって示され,μ-ヒドロキソブリッジのデプロトネーションによって引き起こされます.
結論:
- R2loxコファクターは光活性を示し,照明によって構造的変化を起こします.
- これらの発見は,関連するR2c共因子とR2loxとR2cの異なる機能の理解に影響を与えます.
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