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Updated: Apr 25, 2026

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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APC/Cの2つの化学的阻害剤によってミトスの脱出をシナージスティックにブロックする

Katharine L Sackton1, Nevena Dimova1, Xing Zeng1

  • 11] Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA [2].

Nature
|August 27, 2014
PubMed
まとめ

癌治療は,細胞分裂を調節するタンパク質マシンであるアナフェーズ促進複合体/サイクロソーム (APC/C) を標的とすることができる. 新しい阻害剤であるapcinは,重要なタンパク質の相互作用を妨害することによってAPC/Cの活性を阻害し,潜在的な治療戦略を提供している.

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